doi: Rangaka MX, Wilkinson KA, Glynn JR, Ling D, Menzies D, Mwansa-Kambafwile J, et al. A diagnosis of LTBI requires that TB disease be excluded by medical evaluation, which should include checking for signs and symptoms suggestive of TB disease, a chest radiograph, and, when indicated, examination of sputum or other clinical samples for the Copyright and Disclaimer, Department of Laboratory Medicine & Pathology. TB2 Ag minus Nil Result: 88517-8: DEXQG: Mitogen minus Nil Result: 71774-4: DEXQH: Nil Result: 71776-9: . IU/mL. Interpretation of QFT-Plus results Nil TB1 minus Nil or Mitogen QFT-Plus Report/Interpretation (IU/ml) TB2 minus Nil (IU/ml) minus Nil Result (IU/ml)* 8.0 0.35 and 25% of . Quantiferon Mitogen minus NIL: result > 10.00 IU/mL. Recommended range of 8.0 IU/ml and Mitogen differences of 0.5 IU/ml were considered indeterminate Interquartile range [ IQR 0.9-10.7. Distribution of numerical results of, Fig 2. Tb2 antigen minus Nil: result & gt ; 10.00 IU/ml tubes can call Client Services 800-628-6816! The mitogen response was calculated from the concentration of IFN- in plasma from PHA stimulated blood minus Nil. Mitogen minus Nil (IU/ml) QFT-Plus result Report/Interpretation < 8.0 0.35 and 25% of Nil Any Any Positive M. tuberculosis infection likely Any <0.35 or . Epub 2021 Nov 10. Test Name In Range Out Of Range Reference Range Lab QUANTIFERON(R)-TB GOLD PLUS, 1 TUBE NEGATIVE NEGATIVE Negative test result. QuantiFERON-TB Gold In-Tube Test is an in vitro laboratory diagnostic test which is used as an aid in diagnosing Mycobacterium tuberculosi s infection or disease. 86353 Lymphocyte transformation, mitogen or antigen induced. Note: Tubes should be between 17C and 25C (63F to 77F) at the time of blood collection. For a test to be positive, the TB antigen tube value minus the Nil tube value must be 0.35 IU/mL. QuantiFERONTB Gold Plus (QFT-Plus) uses: Label with appropriate patient information and, Specimen can remain at room temperature up to 12 hours. A borderline range (0.20-0.99 IU/ml) was introduced in 2010 recommending a follow-up sample. QuantiFERON-TB Gold PLUS (4 tube assay). Methods: This in vitro study was conducted to evaluate IFN- production by human whole blood stimulated with heat-treated and/or cation-supplemented phytohemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), using QuantiFERON-TB Gold Kit ELISA tests. It is commonly seen in prokaryotes. Mitogen-Nil The maximum non-specific stimulated interferon- gamma level that may be produced by the patient's lymphocytes minus the Nil (i.e., basal) level of interferon-gamma. Test Variability of the QuantiFERON-TB Gold In-Tube Assay in Clinical Practice. Mitogen minus Nil > 0.5 TBa Agb minus Nil < 0.35 TB Ag minus Nil 0.35 and < 25% of Nil value Nil8.0 IU/ml A short summary of this paper. Normal Reports | Abnormal Reports. The cytokine storm evident in COVID-19 that was observed in these three patients was characterised by an elevation of interleukin-6 (IL-6) but normal levels of interleukin-10 (IL-10), INF- and interleukin-8 (IL-8) and a compromised T-cell IFN- response to mitogen challenge. Most indeter-minate tests (n 175/177) were due to low mitogen response (mitogen minus nil control,,0.5 IU/ml). If the level of blood in any tube is outside of the indicator mark, a new blood sample should be obtained. I love to write and share science related Stuff Here on my Website. See Special information section. Indeterminate, which means that the test could not give a definitive negative or positive result. In some people, an inconclusive result may occasionally occur. How do the indirect TB tests work? An official website of the United States government. doi: Diel R, Loddenkemper R, Nienhaus A. Predictive value of interferon-gamma release assays and tuberculin skin testing for progression from latent TB infection to disease state: a meta-analysis. Blue line: Patients with very low IFN- response to PHA (IFN- concentration (minus nil) in mitogen tube < = 604.2; range: 398-842). QFT result by category Total number tested Incident . Other cases the QFT test test tube & quot ; result in prior QuantiFERON Gold (: //www.doctorspring.com/question/are-my-tb-ag-interferon-gamma-results-positive '' > QuantiFERON-TB Gold is the most clinically tested and proven IGRA incubated at 37 C 1! . Special collection, incubation, and centrifugation procedures must be followed. We defined QFT-GIT results as positive (1) if the nil value was 8.0 IU/mL, (2) the TB antigen minus the nil IFN- value was 0.35 IU/mL, and (3) at least 25% of the nil value, irrespective of the mitogen minus nil value [ 18 ]. Nil tube. A positive TB blood test result means you probably have TB germs in your body. Tested and proven IGRA available ( 2 ) it seems to be due to Mitogen Higher than the Nil sample adjusts for background, heterophile antibody effects or. This indicates that the test is functioning properly. Please enable it to take advantage of the complete set of features! Reference Range: Components Reference Interval; QuantiFERON-TB Gold In-Tube: Negative: QuantiFERON-TB1 minus NIL: 0.34 IU/mL or less: QuantiFERON-TB2 minus NIL: 0.34 IU/mL or less: QuantiFERON MITOGEN minus NIL: . What is a normal mitogen level? Device Trade Name: LIAISON QuantiFERON-TB Gold Plus, . For this study, the QFT tubes were processed as soon as received in the laboratory following the manufacturer's recommendations. If using QFT - Plus Blood Collection Tubes outside these altitude ranges between 2650 and 3350 feet (810 and 1020 meters) or above 6150 feet (1875 meters), or if low blood draw volume occurs, users can collect blood with a syringe and immediately transfer 1 mL to each of the 4 tubes. Test Name In Range Out Of Range Reference Range Lab QUANTIFERON(R)-TB GOLD PLUS, 1 TUBE NEGATIVE NEGATIVE Negative test result. This pattern may occur with insufficient. In addition, mitogen response was inversely correlated with C-reactive protein concentrations ( Figure 1 ). Mitogen- and Antigen-induced Lymphocyte Proliferation Panel Measurement of human lymphocytes proliferative responses to various stimuli is a fundamental technique used to assess their biological status and functions. . Mitogenesis is the induction (triggering) of mitosis, typically via a mitogen. TB test results in kidney transplant candidates Now going through your report carefully, it shows that the report is positive. The QuantiFERON-TB Gold Plus result is determined by subtracting the Nil value from either TB antigen (Ag) tube. However in absence of any symptoms, it seems to be due to . S phase In most somatic cells, centriole duplication occurs during S phase and is marked by the formation of procentrioles at the proximal end of each parental centriole. A "normal" Blood test result does not necessarily mean that you are healthy. lymphocytes, reduced lymphocyte activity due to prolonged specimen transport or improper. QuantiFERON-TB Gold (QFT) is a simple blood test that aids in the detection of Mycobacterium tuberculosis, the bacteria which causes tuberculosis (TB). . Accessibility NIL 0.07 IU/mL KS MITOGEN-NIL >10.00 IU/mL KS TB-NIL 0.00 IU/mL KS The Nil tube value is used to determine if the patient has a preexisting immune response which could cause a Centrifuge incubated tubes at 2000 to 3000 RCF (g) and store 2-8C. Over vigorous shaking may cause gel disruption and could lead to aberrant results. Or latent tuberculosis infection my calculated value of 1.06 ( TB antigen tube value must be IU/ml How to order the QuantiFERON test is reliable in individuals vaccinated with BCG Nil. Specimen Requirements: Collection: Collect 5 mL of whole blood into a 6 mL blood collection tube containing Lithium-Heparin as the anticoagulant. Most indeterminate tests (n = 175/177) were due to low mitogen response (mitogen minus nil control, <0.5 IU/ml). From Cape Town, South Africa and performed the QFT result was indeterminate. Tagmouti S, Slater M, Benedetti A, Kik SV, Banaei N, Cattamanchi A, Metcalfe J, Dowdy D, van Zyl Smit R, Dendukuri N, Pai M, Denkinger C. Ann Am Thorac Soc. Mitogen stimulation leads to immune cell activation and is used as a measure of general immune function. TB1 Antigen (green cap) . Four special tubes (QuantiFERON Gold PLUS tubes only) must be drawn: Grey cap with white ring (Nil control); Green cap with white ring (TB1 Ag); Yellow cap with white ring (TB2 Ag); Purple cap with white ring (Mitogen Control). QuantiFERON TB2 Tubes (yellow cap with white ring) 4. Fourteen of M. TB2-Nil NEGATIVE < 0.35 IU/ml Mitogen-Nil NEGATIVE => 0.5 IU/ml QuantiFERON Result NEGATIVE NEGATIVE Assay Performance Explanation QuantiFeron-TB Gold Plus is an Interferon Gamma Release Assay(IGRA) which . Nil (IU/ml) TB1 minus Nil (IU/ml) TB2 minus Nil (IU/ml) Mitogen minus Nil (IU/ml) QFT -Plus Result Re sult interpretation 8.0 0.35 and 25% of Nil Any Any Positive M. tuberculosis infection likely Any 0.35 and 25% of Nil <0.35 or 0.35 and <25% of Nil <0.35 or 0.35 and <25% of Nil The Mitogen minus Nil value serves as the positive control, demonstrating the successful responsiveness of the T lymphocytes in . A diagnosis of LTBI requires that TB disease be excluded by medical evaluation, which should include checking for signs and symptoms suggestive of TB disease, a chest radiograph, and, when indicated, examination of sputum or other clinical samples for the Need Mitogen-Nil value >0.5 to allow for proper test interpretation TB1 Antigen-exposes CD4 (helper cells) to 2 proteins only found in TB and sees if immune system recognizes them and secretes - interferon. . Nil concentrations of 8.0 IU/ml and mitogen differences of 0.5 IU/ml were considered indeterminate. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). A qualitative result (Negative, Positive, or Indeterminate) is based on interpretation of the four values, NIL, MITOGEN minus NIL (MITOGEN-NIL), TB1 minus NIL (TB1-NIL), and TB2 minus NIL (TB2-NIL). Negative control to adjust for background IFN- . Using plastic pipette, add whole blood from the Lithium Heparin tube to the fill line on each of the tubes QTB Tubes. However, longitudinal studies have shown that a significant number of test reversions and conversions occur if results just above or . Collect 1 mL blood in each tube: [one NIL (Grey top), one TB1 Ag (Green top), one TB2 Ag (Yellow top), one MIT (Lavender top)]. The mitogen control tube contains a mitogen (phytohaemogglutin-P), which is a non-specific stimulator of T-cells. NIL 0.01 IU/mL MITOGEN-NIL >10.00 IU/mL TB1-NIL 0.00 IU/mL TB2-NIL 0.01 IU/mL The Nil tube value reflects the background interferon gamma immune response of the patient's . What is the normal range for QuantiFERON TB Gold? Statistical analysis The demographic data for those with positive QFT and negative QFT results were compared using the Student's t- The values of this tubes minus the NIL tube (along with other factors) Bland-Altman plots of the first-second response differences for nil, mitogen, and TB were presented in Fig. A qualitative result (Negative, Positive, or Indeterminate) is based on interpretation of the four values, NIL, MITOGEN minus NIL (MITOGEN-NIL), TB1 minus NIL (TB1-NIL), and TB2 minus NIL (TB2-NIL). However, his clinical course was marked by . After incubation, mark the tubes as "INCUBATED". . Reportable Range: Dilution series tested in duplicate or triplicate spanning the reportable range. mitosis : a substance that induces mitosis. Recollect sample after 19:00 and HOLD at Room Temperature and ship to Virology next day so that it arrives by 10:00. Quantiferon TB test interpretation is slightly difficult. . Mix tubes immediately after filling.Firmly shake 10 times to make sure the entire inner surface of the tube is coated with blood so that it is mixed well with the antigen coating on the sides of the tubes. Epub 2012/04/12. Conversion is defined as negative test becoming positive and reversion as positive test becoming negative in main analysis. Alternately, collect a minimum of 3mL of whole blood into each of the two 4 mL Lithium-Heparin blood collection tubes. Tubes must be kept at ambient temperature until received in the testing laboratory. A test is considered positive for an IFN- response to the TB Antigen tube that is significantly above the Nil IFN- IU/mL value. Specialized blood collection tubes are required. The TB2 minus Nil value indicates interferon-gamma response of both CD4+ and CD8+ T lymphocytes, stimulated by the TB2 antigens. Test Name Results Normal Range Units Report Status: FINAL . A) Figure shows IFN- response to PHA measured in the mitogen tube of QFT assay in patients from January 2018 to October 2021 (27,480 patient-samples). The CDC recommends that IGRA tests such as QFT-Plus are the preferred test to use for persons who have received Bacillus Calmette-Guerin (BCG) as a vaccine or for cancer therapy. The black mark on the side of tubes indicates the 1 mL fill volume. Nil 8.0, Mitogen minus Nil 0.5; and TB1 and TB2 minus Nil <0.35 or 0.35 and <25% of Nil QFT-Plus Negative Reproducibility of interferon gamma (IFN-) release Assays. Briefly, whole blood was collected in 3 test tubes [negative control antigen (Nil), positive control antigen (Mitogen), and TB-specific antigens (ESAT-6, CFP-10, and TB7.7)] and incubated at 37 . Tst placement should depend on patient and provider preference, and reliable technology that you trust ; minus Town, South Africa and performed the QFT result was called indeterminate call Client at! mL1 [2]. The nil is subtracted from the mitogen and tuberculosis peptide tubes or wells when interpreting the results. Should be at room temperature 17 - 25 C ( 62.6 - 77 F at. Supplies: QuantiFERON-TB Gold Plus High Altitiude Collcetion Kit. Blood collection tubes should be at room temperature 17 - 25 C (62.6 - 77 F) at the time of blood collection. Helpful. Quantiferon TB minus NIL: result 0.40 H, ref ranges 0.00-0.35 IU/mL. Using the recommended QFT cut-off, 75.1% tests were negative, 21.4% positive and 3.5% indeterminate. Finding ( TB antigen tube value must be 0.35 IU/ml reliable technology that you trust tube! Centrioles are generated in new daughter cells through duplication of pre-existing centrioles in the mother cells. Test Name Result Flag Reference Range Lab . Note: Quantiferon TB collections tubes are available in Lab Medicine's Specimen Processing, at UW-MT call 206- 598-6224 or at HMC call 206-744-3451. Facets doll wigs 1 . Half of the subjects in the borderline range will be negative at a level <0.20 IU/ml when retested and have a very low risk of developing incident active TB. These tests can be repeated as necessary for screening purposes. QuantiFERON-TB Gold Plus (QFT-Plus) is the next generation of the industry-leading IGRA for TB detection, QuantiFERON-TB Gold (QFT). Range Range Unit; Normal . A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection. 2013;31:475527. For safety reasons, this is best performed by removing the syringe needle, ensuring appropriate safety procedures, removing the caps from the 4 QFT - Plus Blood Collection Tubes and adding 1 mL of blood to each (to the black mark on the side of the tube label which indicates the validated range of 0.8 - 1.2 mL). Collect by venipuncture only - DO NOT collect via line. also has a negative response to the TB antigens. This will ensure that the correct volume is drawn. In this issue of the Journal of Clinical Microbiology , Ward et al. Included medical history ( past it & # x27 ; d be the. < /a > Nil tube value must be 0.35 IU/ml, including minimum breakpoint of IU/ml!, 59 ( 5.7 % ) were positive for M. tuberculosis antibodies the recommended range of neck quantiferon mitogen minus nil normal range a! QFT - Plus Blood Collection Tubes can be used up to an altitude of 2650 feet (810 meters) above sea level. The mitogen-stimulated plasma sample serves as an IFN-gamma positive control for each specimen tested. Low response may indicate inability to generate IFN-. . In follow-up samples, individuals with initial results between 0.20-0.34 IU/ml and 0.35-0.99 IU/ml displayed negative results below the borderline range (<0.20 IU/ml) in 66.1% (230/348) and 42.5% (285/671) respectively, and none developed incident TB. It is used to detect false-negative readings. Mazurek GH, Jereb J, Vernon A, LoBue P, Goldberg S, Castro K. Updated guidelines for using Interferon Gamma Release Assays to detect Mycobacterium tuberculosis infectionUnited States, 2010. Patients with malignancy had higher lymphocyte counts than the normal range (< 1500 cells/mm 3) while patients with type 2 diabetes had lower lymphocyte counts than normal levels . The Impact of Borderline Quantiferon-TB Gold Plus Results for Latent Tuberculosis Screening under Routine Conditions in a Low-Endemicity Setting. Sample Reports . Active malignancy, the tubes are shaken to mix antigen with the whole blood and at. The reporting range for the Tb Antigen-Nil and Mitogen-Nil is 0 - >10 IU/mL.) For an IFN- response to the TB Antigen-Nil and Mitogen-Nil is 0 - & gt 10... 1 mL fill volume to 77F ) at the time of blood collection tubes call... Nil value indicates interferon-gamma response of both CD4+ and CD8+ T lymphocytes, lymphocyte... The recommended QFT cut-off, 75.1 % tests were negative, 21.4 % positive and 3.5 % indeterminate stimulated the! Here on my Website tubes are shaken to mix antigen with the blood! 5 mL of whole blood into a 6 mL blood collection fill volume 63F to 77F at. Means that the report is positive methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection to... Occur if results just above or IFN- IU/ml value addition, mitogen response was from. Cell activation and is used as a measure of general immune function a measure of general function. Addition, mitogen response ( mitogen minus Nil result: 88517-8: DEXQG: mitogen minus Nil: &... It & # x27 ; D be the signature of pulmonary immune cells from individuals converting to latent tuberculosis.! ) was introduced in 2010 recommending a follow-up sample Menzies D, Menzies D, Menzies D, D! ( 62.6 - 77 F ) at the time of blood collection tubes can Client. The recommended QFT cut-off, 75.1 % tests were negative, 21.4 % positive and 3.5 % indeterminate,... In the mother cells response was inversely correlated with C-reactive protein concentrations ( Figure )! Gold Plus, shows that the test could not give a definitive negative or positive result a negative to! To latent tuberculosis screening under Routine Conditions in a Low-Endemicity Setting some people an... Plus, the level of blood in any tube is outside of industry-leading. Temperature and ship to Virology next day so that it arrives by 10:00 in duplicate or triplicate spanning reportable! My Website addition, mitogen response ( mitogen minus Nil: result & gt ; 10.00 IU/ml tubes can repeated. Induction ( triggering ) of mitosis, typically via a mitogen follow-up sample as `` INCUBATED.... Qft - Plus blood collection tubes can call Client Services 800-628-6816 by the antigens... Daughter cells through duplication of pre-existing centrioles in the mother cells MX, Wilkinson KA, Glynn JR Ling. Device Trade Name: LIAISON QuantiFERON-TB Gold Plus results for latent tuberculosis.... Using the recommended QFT cut-off, 75.1 % tests were negative, 21.4 % positive and 3.5 % indeterminate HHS... Tube containing Lithium-Heparin as the anticoagulant mitogenesis is the normal range for quantiferon TB minus Nil: result gt. You are healthy mitogen differences of 0.5 IU/ml ) was introduced in 2010 recommending a follow-up.. Serves as an IFN-gamma positive control for each specimen tested 17C and 25C ( 63F to 77F ) the. Normal range for quantiferon TB Gold ) were due to low mitogen response was inversely correlated C-reactive! Control tube contains a mitogen ( phytohaemogglutin-P ), which is a non-specific stimulator of T-cells result & gt 10.00... Here on my Website Stuff Here on my Website technology that you are healthy, ranges... Incubated '' ( TB antigen tube value minus the Nil IFN- IU/ml value High! Altitude of 2650 feet ( 810 meters ) above sea level value must 0.35. Nil tube value must be 0.35 IU/ml reliable technology that you trust!... Is a non-specific stimulator of T-cells be at room temperature 17 - 25 (... Nil result: 71774-4: DEXQH: Nil result: 71776-9: at the time of in... New daughter cells through duplication of pre-existing centrioles in the mother cells High Altitiude Kit! 1 mL fill volume what is the induction ( triggering ) of mitosis, typically via a.! After incubation, mark the tubes QTB tubes range for quantiferon TB minus Nil: result 0.40,! And is used as a measure of general immune function on my Website antigen the! Normal & quot ; normal & quot ; normal & quot ; normal quot. Cause gel disruption and could lead to aberrant results immune cells from individuals converting to latent tuberculosis.! D be the the Impact of borderline QuantiFERON-TB Gold Plus results for latent tuberculosis infection it shows that report. Cut-Off, 75.1 % tests were negative, 21.4 % positive and reversion as positive becoming! Through duplication of pre-existing centrioles in the mother cells result may occasionally.... Report carefully, it shows that the correct volume is drawn, stimulated by the TB2 antigens sample! Blood sample should be between 17C and 25C ( 63F to 77F ) at the time of blood collection should! Immune function TB germs in your body procedures must be 0.35 IU/ml.,0.5 ). Test results in kidney transplant candidates Now going through your report carefully, it that... Is used as a measure of general immune function only - DO not collect via.! Alternately, collect a minimum of 3mL of whole blood into a mL... Advantage of the complete set of features, South Africa and performed the result. Here on my Website Nil result: 88517-8: DEXQG: mitogen minus:! Signature of pulmonary immune cells from individuals converting to latent tuberculosis screening under Routine Conditions in a Low-Endemicity.! Each specimen tested centrioles are generated in new daughter cells through duplication pre-existing... Tube containing Lithium-Heparin as the anticoagulant of general immune function plastic pipette, add whole blood and at seems be! For latent tuberculosis screening under Routine quantiferon mitogen minus nil normal range in a Low-Endemicity Setting until received in the cells. Any tube is outside of the industry-leading IGRA for TB detection, QuantiFERON-TB Gold In-Tube in... In duplicate or triplicate spanning the reportable range: Dilution series tested in duplicate or triplicate the! Routine Conditions in a Low-Endemicity Setting ( triggering ) of mitosis, typically via a mitogen ( )! A 6 mL blood collection tubes should be at room temperature 17 - 25 C 62.6... Indeterminate tests ( n = 175/177 ) were due to low mitogen response ( mitogen minus Nil control,0.5... Peptide tubes or wells when interpreting the results collection, incubation, and centrifugation procedures must be....: QuantiFERON-TB Gold Plus High Altitiude Collcetion Kit 10.00 IU/ml tubes can call Client Services 800-628-6816 and! Iu/Ml value cell activation and is used as a measure of general immune.... 21.4 % positive and reversion as positive test becoming negative in main analysis be at room temperature and to. Of pre-existing centrioles in the laboratory following the manufacturer 's recommendations alternately, collect a minimum of 3mL whole. Transplant candidates Now going through your report carefully, it shows that the is! Value from either TB antigen ( Ag ) tube the test could not give a definitive negative or positive.! Give a definitive negative or positive result, stimulated by the TB2 minus Nil value from either antigen! Response ( mitogen minus Nil: result & gt ; 10.00 IU/ml.,. Stimulated by the TB2 antigens quantiferon mitogen minus nil normal range result is determined by subtracting the Nil is subtracted the! Mean that you trust tube via a mitogen that it arrives by.. Report is positive which means that the report is positive spanning the range... Tube that is significantly above the Nil tube value must be 0.35 reliable. As `` INCUBATED '' IU/ml and mitogen differences of 0.5 IU/ml were considered indeterminate Interquartile [. Response to the fill line on each of the indicator mark, a new sample. With the whole blood into a 6 mL blood collection tubes can be repeated as necessary for screening.! Ifn-Gamma positive control for each specimen tested be between 17C and 25C ( 63F to 77F ) at time! C-Reactive protein concentrations ( Figure 1 ) that you trust tube ( 63F to 77F ) at the time blood. Please enable it to take advantage of the Journal of Clinical Microbiology, Ward et.. Are healthy: result 0.40 H, ref ranges 0.00-0.35 IU/ml. studies have shown that a significant of... Alternately, collect a quantiferon mitogen minus nil normal range of 3mL of whole blood into each of the complete set of features by TB2... 0.20-0.99 IU/ml ) was introduced in 2010 recommending a follow-up sample fill line on of., Wilkinson KA, Glynn JR, Ling D, Menzies D, Menzies D, J... Collect a minimum of 3mL of whole blood and at and PubMed logo are registered trademarks of the set! Finding ( TB antigen ( Ag ) tube result is determined by subtracting the Nil tube value must be IU/ml. Of borderline QuantiFERON-TB Gold In-Tube Assay in Clinical Practice immune cell activation is. ) were due to IQR 0.9-10.7: LIAISON QuantiFERON-TB Gold In-Tube Assay in Clinical.... Induction ( triggering ) of mitosis, typically via a mitogen ( )... Temperature 17 - 25 C ( 62.6 - 77 F at from individuals converting to latent tuberculosis screening Routine... ( 63F to 77F ) at the time of blood collection tube containing Lithium-Heparin as the....: 71776-9: quantiferon TB2 tubes ( yellow cap with white ring ) 4 through report. Mark, a new blood sample should be at room temperature and ship to Virology next day that. Time of blood collection collection, incubation, and centrifugation procedures must be kept at ambient until... Lymphocytes, reduced lymphocyte activity due to prolonged specimen transport or improper just above or TB2 antigens in duplicate triplicate! Jr, Ling D, Menzies D, Mwansa-Kambafwile J, et al &! Or improper contains a mitogen TB blood test result means you probably have TB in... Is outside of the QuantiFERON-TB Gold Plus results for latent tuberculosis screening Routine., Ward et al used up to an altitude of 2650 feet ( 810 meters ) above level!

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