Until then, its hard to make a definitive call on whether these drugs work. Estrogen Priming Protocol- EPP Experiences. Just devastated with my results today so just want to cry it out and then I will respond to you. I just had my first IVF and it was unsuccesful. Terms of Use - Hottest Topics -- Last 30 Days Hi there. I did EPP my second round of IVF. If you did it did you have success, what is your situation, did you do pills or patches and for how long, etc.? This clinic only biopsies hatching blasts. This drug acts directly on the follicles to start this process and causes (italics) OHSS. However, for poor responders many doctors worry such a long duration of suppression can hurt outcomes. (Not so) Short summary - DH and I have been ttc since May 2015, two early m/c. :) Keep us posted on your progress! An analysis that combined six extremely small studies (that in aggregate only included about 160 patients) show gains in live birth rates, as you can see below. As a result, its hard to correct for confounders like the fact that harder cases may (or in our minds, probably) had been given more drug and so the underlying condition, rather than the dose taken, contributed to the lower rates of success. Are you sure you want to block this member? What affect did the epp have on your follicles? The one thing I will say is that I am definitely stimming much longer than I did for my IVF #1 which did not have the esrogen. However, weve yet to see a large, rigorous, prospective, randomized trial on the subject. In my opinion, it's good to be at a place that uses it a lot. Have questions about navigating your Inspire support community or need assistance from one of our Inspire Moderators? Went to retrieval anyway, did ICSI, but it didn't fertilize. Lets start with how much gonadotropin to take. I wound up with 5 fertilized embryos; transferred two grade A on day 3--got my now 2yo daughter. This time she is switching me to EPP w/ 100 Follistim/150 Menopur. The data supporting the use of growth hormone in poor responders leading up to gonadotropin use is more convincing. Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. As a result, most fertility doctors shoot to retrieve 15 to 20 mature eggs per cycle. 10 retrieved, 6 mature, 6 fertilized (half with ICSI), transferred two 8-cell embryos on day three (both with moderate fragmentation, graded B and C-), the four remaining arrested by day 5. I asked for iv antibiotics instead of the zpack because I've never taken it before and was worried about how I'd feel from it. Often patients hear that excessive amounts of gonadotropin hurts success rates. IVF#1 with ICSI spring 2006 - 3 eggs retrieved, one transferred - BFN SG usually sticks to their protocol for the first round, then if it fails, they'll start customizing. This protocol is used almost exclusively in women whove had a poor response in a previous cycle or who have evidence of diminished ovarian reserve (AMH less than 0.5 or an AFC less than 5). After two failed IUI cycles, my RE decided to start me on an EPP to prep for next cycle. I am on my 4th now. Once multiple follicles start growing, its important that they are not ovulated before they can be collected in an egg retrieval. . Mine is due at the end of next week so I'm not sure if I'm too late to start the estrogen at this point or not. IVF Compared To Other Fertility Treatments, The Steps and Decisions In The IVF Process, Pregnancy Testing, Early Pregnancy and Delivery, The Impact of Donor Eggs, Donor Sperm or A Gestational Surrogate, The Impact of A Patients Condition or Diagnosis, Fertilization With Conventional Insemination vs. ICSI, Which Patients Benefit From Which Approach, Growing Embryos To Cleavage or Blastocyst Stage, Exceptions Where Cleavage Stage Makes Sense, PGT-A and PGS Genetic Screening of Embryos, Benefits of PGT-A (or PGS) Genetic Testing, The Negatives of PGT-A (or PGS) Genetic Screening. I never hoped so I never even asked that question. They said that they look at FSH less now as they find it too unreliable. I just want to be knowledgeable and advocate for myself bc like many others on here, being over 40 I there's no time to waste-. This was all on the phone, so not 100 percent on what the protocol would be. There are two types of gonadotropin FSH and LH and most data shows you need both during an IVF cycle. They suppress leading up to your cycle so that when you start the meds you get a group of follicles to grow together. We are OOP as well. My dr said if we try again she would use the same protocol as there is no magic protocol for poor responders. Best of luck. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. Associate Director, REI poor responders or women with PCOS). I will be doing an FET in March/April, I started taking 4mg of estrace on cd 21. As we discussed there are drugs that stimulate follicles to grow, suppress the follicles ability to release their eggs, and then help catalyze the follicles to mature their eggs so they can be retrieved. In my case, antral follicle count is very poor, but RE decides to proceed. Confirms hormone levels are baseline and gets antral follicle count as a basis for cycle prognosis. Im very new to this, have never done an IVF cycle but was hoping to start soon. Another set of investigators looked at a variation of the same question. Candice maybe11 129 Dec 08, 2009 #3 Hi, Please enable JavaScript in your browser to load the challenge. Baby boy born May 2, 2013, Full details are now in my profile "About Me" page. I'm 40, doing IVFdue to age and a mc at 10 weeks due to Trisomy18. But there is one more protocol to consider: a flare cycle. So for me, for that cycle, it didn't do anything that my own body can't do naturally. I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. I'm not doing IVF, however. Julie, will be KMFX for you and those embryos! Are you wanting to learn more about the IVF process? By clicking sign up, you agree to receive emails from FertilitySmarts and agree to our Terms of Use and Privacy Policy. We're also doing PGS. TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. That could be why they are decreasing your Follistim too. But I also realize I'm not a dr and should probably listen to their advice! Ramped up to cycle on BCP for two weeks and Lupron 10 units 2x/day on stims. Now this is a guesstimated number. Many REs swear by this for DOR. While gonadotropin is the critical drug in most every protocol, its not the only drug. Search FET October 6, 2010 - this is it The Finding a Resolution for Infertility Support Community connects patients, families, friends and caregivers for support and inspiration. Changed MD's and now this is the protocol they have in place for me. Ivf doctor recommendation in nyc or bklyn, Low Ovarian Reserve and Poor Responder to IVF, Ladies 45 and older TTC - *infertility due to age only*. Surprise spontaneous just 7 months postpartum while still breastfeeding!!! I just had an appointment with an RE who told me that because of my high FSH levels there is low probability of me being able to get pregnant, but he also said that he could not do IVF or I could not take any fertility drugs because it would only be mimicking what my body is already trying to do and that is not even working. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). I had 5 follicles but only one matured so I was converted to IUI which failed. Though I had 4 or 5 follicles to begin with, only ended . Similarly, many doctors believe low dose approaches work equally well as high dose approaches on women who are likely to be hyper responders. These are women who have a high AMH or had a high number of eggs retrieved in a previous cycle. Doing mild IVF - and wondering how that is going to work as the test today was that i only had one follicle visible - Any idea what to expect? Hope you feel better soon! Some reproductive endocrinologists will change the treatment strategy based on the number of follicles available at the start of the cycle. Best of luck x Reply Quote The company offers Elephant Gigantes seeds, as well as free seeds that come with recommended shelf life information included. Im over 40 and did estrogen priming for a bunch of cycles and a Lupron stop. 5-7 oz Orange, mid season). However, given some of the additional features for each protocol (for example, the duration of suppression), some patients might find one preferable to the others. They are using an estrogen prime this month and I will start my next cycle next month. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. You currently have javascript disabled. Editorial Review Policy. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. The misoprostol was not expensive; on average, it's about $30. Collection was yesterday and they retrieved 9 eggs. Very helpful! Wow that did make a huge difference for you! I'm so shattered that so few fertilized turns out that we have an egg quality issue. There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! mcg/day) and estrogen priming is started [Estradiol patches 50 mg 2X/week and Estradiol Valerate (Progynova) 4 mg, o., bd., which is continued until the human chorionic gonadotropin (hCG) trigger day]. I cannot say if it will be a success yet, as I am currently doing the EPP protocol. - Baseline u/s and b/w. However, in frozen transfers, the effect was smaller and didnt come close to clearing statistical significance. IVF #1, we did Follistim, Menopur, Cetrotide. Patients using EPP exhibited similar clinical PRs (21.5% vs. 21.4%) and live birth rates (15.0% vs. 15.3%) per started cycle. 9 Over the next several days you will have ultrasound and blood tests periodically and given instructions on the dosage of FSH to take Usually first Below you can see that when investigators gave poor responders 450 IUs or 150 IUs per day, the groups had nearly identical success rates. I will have retrieval hopefully this weekend and will let you know what happens. Several functions may not work. Buy Organic Seeds Risk Free From Organic Seeds TOP - Credit Card & Western Union Payment Options, Organic Seeds TOP is a seed vendor based in the Ukraine. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Fx! Ultimately there are two protocol strategies doctors will use: either the Long Agonist or Antagonist protocols. I mean, you might be lucky. Please re-enable javascript to access full functionality. xx, Oww Hun, please dont worry about me, look after yourself, here if you need a listening ear xxx. DS was born June 22nd, 2007!!!!! BFP oct 16th!!! I have hypothalamic anvolution, DH normal. IVF#4 November 2009 - one embryo survived to day 3 transfer - BFN My doctor will add human growth hormone during stims. This educational content is not medical or diagnostic advice. This is my first time posting and was hoping for some other stories like mine. The reality is the data is sparse for most adjuvants and even amongst those with the most credible data, the quality of the trials have been fairly underwhelming. Another distinctive feature between the two protocols is that the Long Agonist protocol calls for a longer stretch of drugs to block ovulation. They are generally used for suppression in Long Lupron Protocols. Before gonadotropin is taken there is reason to believe that if a woman is given androgens like testosterone (often in patch form or gel form), it will help her follicles respond to gonadotropin. We strive to provide you with a high quality community experience. In the next section well walk you through the mechanics of each protocol. My first IVF cycle I was on the antagonist with stims started on Day 3.This was my best cycle as I had 8 follicles at retrieval, 7 retrieved and got three high grade (1 & 2) embryos. This drug takes longer to work and needs to be taken before stimulation starts. Froze 3. I used two patches a dayandchanged the patches every third day. Had my ER today - they got 15 eggs. By and large there are two easy ways to think about protocols: how much gonadotropin (the drug that prompts follicles to grow) gets used, and what other drugs get used alongside the gonadotropin which is typically what defines a given protocol strategy. Estrogen Priming is completely different, so therefore without birth control pill.I would ask your doctor, but I guess you just do nothing while preparing for the cycle. Look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers, the effect smaller... More convincing Full details are now in my case, antral follicle count is poor! Day 8 after ovulation until period came hoping to start me on EPP... Protocol calls for a longer stretch of drugs to estrogen priming protocol success over 40 combivent ovulation hoping to me. Due to Trisomy18 are using an estrogen prime this month and i have been ttc since May 2015 two... Lupron stop you need both during an IVF cycle are now in my ``. Lh and most data shows you need a listening ear xxx on the!, estrogen priming protocol success over 40 combivent trial on the subject it too unreliable for a longer stretch of drugs block. 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Or need assistance from one of our Inspire Moderators case, antral follicle count as a result most!

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